A redshift survey towards the CMB Cold Spot

We have carried out a redshift survey using the VIMOS spectrograph on the VLT towards the Cosmic Microwave Background cold spot. A possible cause of the cold spot is the Integrated Sachs-Wolfe effect imprinted by an extremely large void (hundreds of Mpc in linear dimension) at intermediate or low redshifts. The redshift distribution of over seven hundred z<1 emission-line galaxies drawn from an I-band flux limited sample of galaxies in the direction of the cold spot shows no evidence of a gap on scales of Delta-z> 0.05 as would be expected if such a void existed at 0.35<z<1. There are troughs in the redshift distribution on smaller scales (Delta-z ~0.01) indicating that smaller scale voids may connect regions separated by several degrees towards the cold spot. A comparison of this distribution with that generated from similarly-sized subsamples drawn from widely-spaced pointings of the VVDS survey does not indicate that the redshift distribution towards the cold spot is anomalous or that these small gaps can be uniquely attributed to real voids.Comment: MNRAS in press, 6 page

Re-evaluation of the first synthetic estrogen, 1-keto-1,2,3,4-tetrahydrophenanthrene, and bisphenol A, using both the ovariectomised rat model used in 1933 and additional assays

1-Keto-1,2,3,4-tetrahydrophenanthrene (THP-1) was reported by Cook et al in 1933 as the first synthetic estrogen. Estrogenic activity was assessed by the induction of vaginal cornification in ovariectomised rats. The corresponding 4-isomer (THP-4) was shown to be inactive. Both chemicals have been re-synthesised and assessed for hormonal activity. Each chemical bound weakly and to the same extent to isolated estrogen receptors, but only at high concentrations. However, they each lacked estrogenic or anti-estrogenic activity when evaluated in vitro using a yeast hER assay, and both failed to induce vaginal cornification or uterotrophic effects in ovariectomised rats. THP-1, and to a lesser extent THP-4, were shown to possess weak androgenic and anti-androgenic activity in vitro when evaluated using an hAR yeast assay. Estrogenic activity for bisphenol A (BPA) was subsequently demonstrated by Dodds and Lawson (1936) using the same ovariectomised rat protocol, and this activity has been confirmed and supplemented by positive uterotrophic effects for BPA in the same bioassays. The present results illustrate the complexity of deriving conclusions regarding the hormonal activities of chemicals. First, some activities observed in isolated hormonal receptor binding assays may not be expressed in functional hormonal assays. This indicates the need for functional hormonal assays in any screening programme. Second, that activities observed for a chemical in one hormonal assay may not be reflected in related hormonal assays. This indicates the need to define assay protocols with some precision when incorporating them into screening batteries. Finally, that some literature reports of hormonal activity for chemicals may not be capable of independent confirmation under apparently identical conditions of test. This illustrates the need to use lists of hormonally active chemicals with car

Unveiling hidden structures in the Coma cluster

We have assembled a large data-set of 613 galaxy redshifts in the Coma cluster, the largest presently available for a cluster of galaxies. We have defined a sample of cluster members complete to b$_{26.5}=20.0$, using a membership criterion based on the galaxy velocity, when available, or on the galaxy magnitude and colour, otherwise. Such a data set allows us to define nearly complete samples within a region of 1~\Mpc\ radius, with a sufficient number of galaxies per sample to make statistical analyses possible. Using this sample and the {\em ROSAT} PSPC X--ray image of the cluster, we have re-analyzed the structure and kinematics of Coma, by applying the wavelet and adaptive kernel techniques. A striking coincidence of features is found in the distributions of galaxies and hot intracluster gas. The two central dominant galaxies, NGC4874 and NGC4889, are surrounded by two galaxy groups, mostly populated with galaxies brighter than b$_{26.5}=17$ and well separated in velocity space. On the contrary, the fainter galaxies tend to form a single smooth structure with a central peak coinciding in position with a secondary peak detected in X--rays, and located between the two dominant galaxies; we suggest to identify this structure with the main body of the Coma cluster. A continuous velocity gradient is found in the central distribution of these faint galaxies, a probable signature of tidal interactions rather than rotation. There is evidence for a bound population of bright galaxies around other brightest cluster members. Altogether, the Coma cluster structure seems to be better traced by the faint galaxy population, the bright galaxies being located in subclusters. We discuss this evidence in terms of an ongoing accretion of groups onto the cluster.Comment: to appear in A&A, 19 pages, uuencoded gzipped postscript fil

Long-term changes in the diel vertical migration behaviour of zooplankton

Samples historically collected and analysed by the Continuous Plankton Recorder survey were used to examine long-term (1958 to 1994) patterns in the normal diel vertical migration (NDVM) behaviour of 7 copepod taxa in the North Sea: Calanus finmarchicus C5-C6; Calanus spp. C1-C4; Centropages typicus; Centropages hamatus; Temora longicornis; Acartia clausii and Para-Pseudocalanus (this last group included all Paracalanus and Pseudocalanus species). The ratio of night:day abundance near the surface was used as a measure of the extent of NDVM. For all 7 taxa, the extent of NDVM between 1958 and 1994 co-varied with the abundance of herring Clupea harengus in the North Sea. Fisheries data show that during this period the herring stock was a good indicator of the overall abundance of planktivorous fish in the North Sea. These results suggest that changes in the abundance of planktivorous fish in the North Sea over recent decades have resulted in modifications in the NDVM behaviour of many zooplankton taxa

The rodent uterotrophic assay: Critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay

The major protocol features of the immature rat uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the test animals, the maintenance diet used, and the specificity of the assay for estrogens. It is concluded that three daily oral administrations of test chemicals to 21- to 22-day-old rats, followed by determination of absolute uterus weights on the fourth day, provide a sensitive and toxicologically relevant in vivo estrogenicity assay. Rats are favored over mice for reasons of toxicological practice, but the choice of test species is probably not a critical protocol variable, as evidenced by the similar sensitivity of rats and mice to the uterotrophic activity of methoxychlor. Vaginal opening is shown to be a useful, but nondefinitive, adjunct to the uterotrophic assay. The ability of test chemicals to reduce or abolish the uterotrophic response of estradiol is suggested to provide a useful extension of the uterotrophic assay for the purpose of detecting antiestrogens. The results of a series of studies on the environmental estrogen nonyl phenol (NP), and its linear isomer n -nonyl phenol, confirm that branching of the aliphatic side chain is important for activity. 17beta-Desoxyestradiol is shown to be of similar activity to estradiol in the uterotrophic assay and is suggested to represent the "parent" estrogen of NP. Benzoylation of NP and 17-desoxyestradiol did not affect their uterotrophic activity, in contrast to the enhancing effect of benzoylation on estradiol. Selected chemicals shown to be active in the immature rat uterotrophic assay were also evaluated in an in vitro yeast human estrogen receptor transactivation assay. Most of the chemicals gave similar qualitative responses to those seen in the uterotrophic assay, and the detection of the estrogen methoxychlor by the yeast assay evidenced a degree of intrinsic metabolic competence. However, the assay had a reduced ability (compared to rodents) to hydrolyze the benzoate ester of estradiol, and the estrogenic benzoate derivative of NP was not active in the yeast assay. These last results indicate that current metabolic deficiencies of in vitro estrogenicity assays will limit the value of negative data for the immediate future. The results described illustrate the intrinsic complexity of evaluating chemicals for estrogenic activities and confirm the need for rigorous attention to experimental design and criteria for assessing estrogenic activity

Formalizing Inflectional Paradigm Shape with Information Theory

“Paradigm shape,” our term for the morphological structure formed by implicative relations between inflected forms, has not been formally quantified in a gradient manner. We develop a method to formalize paradigm shape by modeling the joint effect of stem alternations and affixes. Applied to Spanish verbs, our model successfully captures aspects of both allomorphic and distributional classes. These results are replicable and extendable to other languages

Data-driven unsupervised clustering of online learner behaviour

The widespread adoption of online courses opens opportunities for analysing learner behaviour and optimising web-based learning adapted to observed usage. Here we introduce a mathematical framework for the analysis of time series of online learner engagement, which allows the identification of clusters of learners with similar online temporal behaviour directly from the raw data without prescribing a priori subjective reference behaviours. The method uses a dynamic time warping kernel to create a pairwise similarity between time series of learner actions, and combines it with an unsupervised multiscale graph clustering algorithm to identify groups of learners with similar temporal behaviour. To showcase our approach, we analyse task completion data from a cohort of learners taking an online post-graduate degree at Imperial Business School. Our analysis reveals clusters of learners with statistically distinct patterns of engagement, from distributed to massed learning, with different levels of regularity, adherence to pre-planned course structure and task completion. The approach also reveals outlier learners with highly sporadic behaviour. A posteriori comparison against student performance shows that, whereas high performing learners are spread across clusters with diverse temporal engagement, low performers are located significantly in the massed learning cluster, and our unsupervised clustering identifies low performers more accurately than common machine learning classification methods trained on temporal statistics of the data. Finally, we test the applicability of the method by analysing two additional datasets: a different cohort of the same course, and time series of different format from another university

Analysing engagement in an online management programme and implications for course design

We analyse engagement and performance data arising from participants’ interactions with an in-house LMS at Imperial College London while a cohort of students follow two courses on a new online postgraduate degree in Management. We identify and investigate two main questions relating to the relationships between engagement and performance, drawing recommendations for improved guidelines to inform the design of such courses

Unsung heroes: who supports social work students on placement?

Since the introduction of the three year degree programme in 2003, social work education has undergone a number of significant changes. The time students spend on placement has been increased to two hundred days, and the range of placement opportunities and the way in which these placements have been configured has significantly diversified. A consistent feature over the years, however, has been the presence of a Practice Educator (PE) who has guided, assessed and taught the student whilst on placement. Unsurprisingly, the role of the PE and the pivotal relationship they have with the student has been explored in the past and features in social work literature. This paper, however, concentrates on a range of other relationships which are of significance in providing support to students on placement. In particular it draws on research to discuss the role of the university contact tutor, the place of the wider team in which the student is sited, and the support offered by family, friends and others. Placements and the work undertaken by PE’s will continue to be integral to the delivery of social work education. It is, however, essential to recognise and value the often over looked role of others in providing support to students on placement